Most of the ones I would pick have already been chosen so I'll add two of my own
Herman Tilke - Love him or hate him, his tracks have played a part in the modernisation of F1 in the 21st century and quite a few of his tracks have been quite successful as well, and in reality, most of the qualms people have with his circuit designs are things that are out of his control such as circuit width and run off areas as they are put in force by the FIA and also circuit locations in countries which shouldn't really be hosting F1 races
Imola 1994 - a really sad inclusion, but that weekend changed the face of modern F1, safety features and track 'sanitisation' following the deaths of Ratzenberger and Senna and that led to what we see today, Kubica walking away from Canada 2007 and only missing one race, Webber flying upside down at Valencia in 2010 and walking away completely unharmed, while it'll never be completely safe, Imola 1994 quickened up the pace of the implementation of safety measures to the cars and drivers